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This particular Assignment references the syllabus chosen for the subject of Biochemistry, for the January 2024 - December 2024 session. The code for the assignment is BBCCT-127 and it is often used by students who are enrolled in the BSC (Honours) Degree.
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PART-(A)
1. Distinguish between the following:
a) primary lymphoid organs and secondary lymphoid organs
b) agranulocytes and granulocytes
2. a) How a pathogen is internalized? Explain with the help of diagram.
b) Enlist and enumerate the steps for leukocyte extravasation?
3. Discuss alternate pathway of complement activation.
4. How following factors influence the immunogenicity?
a) Traits of Host
b) Traits of Immunogen
5. Describe Tonegawa and Hozumi experiment.
PART-(B)
6. Explain stages and steps of B-lymphocyte maturation.
7. Give an overview of pathways of antigen processing and presentation.
8. Discuss different types of CD4+ Helper T cells.
9. Differentiate between the following:
i) TCR and Immunoglobulin
ii) Positive and Negative T-cell selection
10. Describe the following:
a) IgE mediated hypersensitivity.
b) Active and Passive Immunization
PART-(A)
1. Write short note on the following:
a) Natural killer cells
b) Lymph nodes
c) Interleukins
d) Adjuvant
2. a) How a pathogen is killed by oxygen dependent and oxygen independent pathways?
b) Illustrate the Properties of B and T-cell epitopes?
3. Discuss classical pathway of complement activation.
4. Differentiate between:
a) Antigen and Immunogen
b) Immunoglobulin G and Immunoglobulin M
5. Describe ways of antibody diversification.
PART-(B)
6. Give an overview of T- cell development.
7. Write short note on the following:
a) Role of MHC I and II
b) CD4+Helper T-cells
8. Discuss Type III and Type IV Type Hypersensitivity.
9. Differentiate between the following:
i) Endogenous and Exogenous antigen
ii) DNA vaccines and Purified macromolecules as vaccines
10. Describe the Immunological basis of graft rejection.
भाग- (क)
1. निम्नलिखित में अंतर बतायें:
क) प्राथमिक लिम्फोइड अंग तथा द्वितीयक लिम्फोइड अंग
ख) एग्रानुलोसाइट्स और ग्रैन्यूलोसाइट्स
2. क) एक रोगजनक का आंतरिककरण कैसे किया जाता है? चित्र की सहायता से समझायें।
ख) ल्यूकोसाइट परिस्त्रवण के चरणों को सूचीबद्ध करें और गिनाये ।
3. पूरक सक्रियण वैकल्पिक मार्ग पर चर्चा करें।
4. निम्नलिखित कारक इम्यूनोजेनेसिटी को कैसे प्रभावित करते हैं?
क) परपोषी / मेजबान के लक्षण
ख) इम्यूनोजेन के लक्षण
5. टोनेगावा और होजुमी प्रयोग का वर्णन करें।
भाग- (ख)
6. बी- लिम्फोसाइट परिपक्वन के चरण की व्याख्या करें।
7. एंटीजन प्रसंस्करण और प्रस्तुति के मार्गों का अवलोकन करें।
8. विभिन्न प्रकार की CD4+ सहायक t कोशिकाओं पर चर्चा करें।
9. निम्नलिखित के बीच अंतर करें
क) टीसीआर और इम्यूनोग्लोबुलिन
ख) पॉजिटिव और निगेटिव चयन
10. निम्नलिखित का वर्णन करें:
क) IgE मध्यस्थ अतिसंवेदनशीलता
ख) सक्रिय और निष्क्रिय टीकाकरण
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