IGNOU MFN-02
- Nutritional Biochemistry,
Latest Solved Assignment
(July 2024 - January 2025)

Section A –Descriptive Questions

1. a) What is stero-isomerism? Explain giving an example.
b) What are polysaccharides? What are its types? Explain giving examples.

2. a)Give the classification of lipids based on the chemical structure.
b) What is hydrogenation? What are the harmful health effects of partial hydrogenation of fats?
c) Give the general structure of amino acid with one example each of polar, non-polar, acidic and basic amino acids.

3. a) How will you classify Vitamins based on their solubility?
b) Briefly explain the mechanism of enzyme action.
c) Differentiate between competitive and non-competitive enzyme inhibition.

4. a) Explain the process of carbohydrate digestion in our body.
b) What is the role of pancreas in digestion?

5. a) Briefly explain how blood glucose level is regulated in the body?
b) What is the net production of ATP when one molecule of glucose is converted to pyruvic acid?
c) Briefly explain the components of electron transport chain.

6. a) What is the site for the synthesis of fatty acids? Explain giving the reactions involved in the de-novo synthesis of fatty acids.
b) Define Lipoprotein and apolipoprotein with suitable examples.

7. a) What are Ketogenic and Glucogenic amino acids? Discuss their fate in our body.
b) What is the end product of purine degradation and what disease is caused because of this?

8. a) Give the role of free radicals and antioxidants in lipid peroxidation.
b) Discuss the role of Vitamin K in the coagulation of blood.
c) Enumerate the physiological role of iron.

9. a) Illustrate the role of parathormone in calcium homeostasis.
b) Enumerate the different second messengers used in mechanism of hormone action.

10. a) List the common inborn errors due to protein metabolism. Explain briefly any two of them.
b) Differentiate between sickle cell anaemia and thalasemia.

Section B - OTQ (Objective Type Questions)

1. Explain the following in 2-3 sentences. Also give the structure wherever possible.

a. Osazone reaction
b. Eicosanoids
c. Isoelectric pH
d. Holoenzyme
e. Pinocytosis
f. Ketosis
g. Cyclic AMP
h. Folate Trap
i. Transamination
j. Anaplerotic reactions

2. Name the defective enzyme in the following diseases:

a) Tyrosinemia
b) Phenylketonurea
c) Alkaptonurea
d) Niemann-Pick-Disease
e) Von-Gierk’s Syndrome

3. Match the items in List I with items in List II :

Section A –Descriptive Questions
There are ten questions in this part. Answer all questions.
1. a) What is starch? Give its biochemical structure.
b) List the important reactions of monosaccharides. Explain any two in detail.
c) Give an example of a Trisaccharide.What is it made up of?

2. a)What are Eicosonoids? Briefly describe their role in the body.
b) Discuss the four basic structural levels of proteins, giving examples.

3. a) List the different classes of enzymes. Explain any two in detail.
b) Explain briefly the three major classes of enzyme inhibition?
c) Name the enzymes whose blood levels are determined during clinical diagnosis of nephrotic syndrome.

4. a) Describe the role of enzymes in digestion of food in the body.
b) Explain the process of absorption and transport of lipids in our body.

5. a) What is gluconeogenesis? Discuss the four substrates used in gluconeogenesis.
b) What is Phosphogluconate pathway? Give any three significance of this pathway.

6. a) Write briefly the steps involved in cholesterol synthesis in the body.
b) What do you understand by the term hyperproteinemias.
c) Name three ketone bodies seen in ketosis.

7. a) Explain the Urea cycle indicating the enzymes and co-enzymes involved in it.
b) Explain the different ways by which non essential amino acid is biosynthesised .

8. a) Describe the role of free radicals in lipid peroxidation.
b) What are antioxidants? Give their classification and role in brief.

9. a) Indicate the steps involved in formation of vitamin D3.
b) Why minerals are essential for us? Give the biochemical role of zinc in our body.

10. a) What do you understand by the term “inborn errors of metabolism”?
b) Differentiate between Group I and Group II hormones, giving examples.

Section B - OTQ (Objective Type Questions)
1. Explain the following in 2-3 sentences. Also give the structure wherever possible.
a. Isomer
b. Essential fatty acids
c. Isoprene
d. Turnover number
e. Brush border
f. Electron Transport Chain
g. Ketosis
h. Metalloflavoproteins
i. Transcription
j. Allosteric mechanisms

2. Name the defective enzyme in the following diseases:
a) Alcaptonuria
b) Gaucher’s disease
c) Homocystinuria
d) Pentosuria
e) Albinism

3. Match the items in List I with items in List II :
List I                                              List II
I Maltose                                        A Glucose + Maltose
II Type IV hyperproteinemia     B Glucose + Glucose
III Sucrose                                     C Glucose + Galactose
IV Type II a hyperproteinemia  D Glucose + Fructose
V Lactose                                        E Increase cholesterol +Triglyceride
F Increase cholesterol +LDL
G Increase cholesterol +Triglyceride+VLDL