PART-(A)
1. Distinguish between the following:
a) primary lymphoid organs and secondary lymphoid organs
b) agranulocytes and granulocytes
2. a) How a pathogen is internalized? Explain with the help of diagram.
b) Enlist and enumerate the steps for leukocyte extravasation?
3. Discuss alternate pathway of complement activation.
4. How following factors influence the immunogenicity?
a) Traits of Host
b) Traits of Immunogen
5. Describe Tonegawa and Hozumi experiment.
PART-(B)
6. Explain stages and steps of B-lymphocyte maturation.
7. Give an overview of pathways of antigen processing and presentation.
8. Discuss different types of CD4+ Helper T cells.
9. Differentiate between the following:
i) TCR and Immunoglobulin
ii) Positive and Negative T-cell selection
10. Describe the following:
a) IgE mediated hypersensitivity.
b) Active and Passive Immunization
PART-(A)
1. Write short note on the following:
a) Natural killer cells
b) Lymph nodes
c) Interleukins
d) Adjuvant
2. a) How a pathogen is killed by oxygen dependent and oxygen independent pathways?
b) Illustrate the Properties of B and T-cell epitopes?
3. Discuss classical pathway of complement activation.
4. Differentiate between:
a) Antigen and Immunogen
b) Immunoglobulin G and Immunoglobulin M
5. Describe ways of antibody diversification.
PART-(B)
6. Give an overview of T- cell development.
7. Write short note on the following:
a) Role of MHC I and II
b) CD4+Helper T-cells
8. Discuss Type III and Type IV Type Hypersensitivity.
9. Differentiate between the following:
i) Endogenous and Exogenous antigen
ii) DNA vaccines and Purified macromolecules as vaccines
10. Describe the Immunological basis of graft rejection.
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